ABSTRACT:
The present study investigates the stability behavior and antimicrobial activity of Cu (II), Co (II), and V(IV) complexes of the hydrazone ligand 2-[(E)-{2-[hydroxy(phenyl)methyl] hydrazinylidene} methyl] phenol (HMP). The ligand, previously synthesized via condensation of 2-hydroxy-6-methylbenzaldehyde with hydrazinephenylmethanol, acts as a bidentate donor through azomethine nitrogen and phenolic oxygen atoms. Metal complexes were prepared in a 2:1 (M: L) ratio and their stability was assessed using spectrophotometric techniques, complemented by thermal analysis. Formation constants and thermodynamic parameters were evaluated to elucidate the strength and nature of metal–ligand interactions. The complexes exhibited appreciable stability, with stability trends consistent with metal ion properties and coordination geometry. Antimicrobial screening against selected Gram-positive, Gram-negative, and fungal strains revealed enhanced biological activity of the metal complexes compared to the free ligand, which is attributed to increased lipophilicity and chelation effects upon coordination. Among the complexes studied, the Cu (II) complex demonstrated the highest antimicrobial efficacy, correlating with its observed stability parameters. The combined stability and biological results suggest that HMP-based transition metal complexes possess promising potential for further bioinorganic and pharmaceutical investigations.
Cite this article:
Kizito O. Eberendu. Spectrophotometric Stability Studies and Antimicrobial Assessment of Cu (II), Co (II), and V(IV) Complexes Derived from 2-[(E)-{2-[Hydroxy(phenyl)methyl] hydrazinylidene} methyl] phenol. Research Journal of Science and Technology. 2026; 18(3):247-3. doi: 10.52711/2349-2988.2026.00034
Cite(Electronic):
Kizito O. Eberendu. Spectrophotometric Stability Studies and Antimicrobial Assessment of Cu (II), Co (II), and V(IV) Complexes Derived from 2-[(E)-{2-[Hydroxy(phenyl)methyl] hydrazinylidene} methyl] phenol. Research Journal of Science and Technology. 2026; 18(3):247-3. doi: 10.52711/2349-2988.2026.00034 Available on: https://www.rjstonline.com/AbstractView.aspx?PID=2026-18-3-1
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